There are 14 research groups at MCCIR, each focusing on a specific area of inflammation research.
Dendritic cells (Professor Andrew MacDonald)
Determining how Type 2 immunity is initiated, maintained and regulated, with the ultimate goal of identifying cellular and molecular targets for rational development of therapeutics.
Homeostasis and pathogenesis (Professor Silvia Bulfone-Paus)
Investigating the role that mast cells play in controlling tissue homeostasis and pathogenesis.
Imaging and immunology (Professor Daniel Davis)
Probing the dynamics of immune cell biology using novel and state-of-the-art imaging technology, including immune synapses.
Immune checkpoints (Dr Peter Cook)
Understanding how specific cells in the immune system that are key for activating inflammation start to respond to Aspergillus spores and trigger allergic disease symptoms.
Immune responses in the intestine (Dr Mark Travis)
Studying the pathways that regulate T-cell responses in the intestine and how changes in this regulation can result in inflammatory bowel disease.
Inflammation at mucosal barrier sites (Dr Matthew Hepworth)
Understanding the immune pathways that normally act to prevent inflammation at mucosal barrier tissue sites in health.
Inflammatory cell function during infection (Dr John Grainger)
Understanding how tissue specific signals condition the function of recruited cell populations.
Lung immunity in health and disease (Professor Tracy Hussell)
Understanding how inflammation is inhibited in the healthy lung.
Balancing immune responses in lung pathology (Dr Tara Sutherland)
Investigating the key initiating immune mechanisms that influence the development of allergic airway inflammation.
Molecular mechanisms inflammation (Dr Gloria Lopez-Castejon)
Understanding the mechanisms by which known danger signals trigger inflammasome activation
Inflammation, tissue recovery and repair (Dr James Fildes)
Exploring the mechanisms of regulation of the immune response to endogenous cellular stress, with a focus on the heart and lungs.
Skin inflammation (Dr Amy Saunders)
Understanding the skin immune system with a particular focus on mechanisms that actively maintain immune cell tolerance in healthy skin.
Tissue-specific immune cell networks (Dr Joanne Konkel)
Understanding how the immune system is tailored to unique barrier surfaces and how these networks evolve with age.
Intestinal macrophages (Elizabeth Mann)
The intestinal immune system is highly specialised to maintain the delicate balance between tolerance towards the trillions of harmless bacteria.